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                汪小我 副教授

                清華大學碰撞自動化系
                信息處※理研究所 副所長
                清華信息科學绝对是天方夜谭與技術國家實驗室(籌)生那深蓝色光芒之中物信息學部
                清華大學合成與系統生物中心
                生物信息學教育部重點身上九彩光芒继续暴涨而起實驗室

                通訊地址:北京清華大學FIT 1-112室 郵編:100084
                電話:010-62794294 轉808
                Email: xwwang@tsinghua.edu.cn   

                 

                展開
                教育背景

                1999年8月–2003年7月 清華大學,自動化系,自動化專業,學士

                2007年9月–2008年3月 美國冷眼中精光爆闪泉港實驗室,訪問學生

                2003年9月–2008年7月 清華大學,自動化系,控制科學與工程,博士   


                 

                工作履歷

                2008年7月–2011年11月 清華大學,自動化系,講師
                2011年12月–2015年12月 清華大學,自動化系,副教授
                2012年3月–2013年3月 美國加州大學伯克利分等到时候出去试一试就知道了校,唐氏傑出學者
                2016年1月–現在 清華大學,自動化系,長聘副教授(Tenure,PI,博士生導師)

                學術兼職

                中國人工智能學會生物信息學與人工生命沉声开口專業委員會秘書長

                中國生物工程學會計算生物學與生物信息學專業委員會委員

                國家自然科學』基金、香港GRC項目函評人

                擔任Nature Biotechnology, PNAS, Genome Biolgy, Bioinformatics、PLoS Computational Biology,《科學通報》、《中國科學》等國惧怕自己內外期刊和會議的審稿人   

                研究領域

                1.生物信息學研究

                2.生物組學大數據的信息挖掘

                3.模式識別與機器學習方法及應用

                4.合成生物系統的設計與控制

                獎勵@與榮譽

                國眼中精光爆闪家自然科學基金優秀青年基金,2013

                教育部新世紀優秀人ξ 才,2013

                全國優秀博士學位論文,2010

                中國自動化學會科學技術進步獎二等獎(排名第二),2013

                國家教學成气势果二等獎(排名第五),2009

                北京市教學成果一等獎(排名第五),2008

                學術成果

                1.Chao He?, Guipeng Li?, Diekidel M. Nadhir, Yang Chen* , Xiaowo Wang,*  and Michael Q. Zhang*, Advances in computational ChIA-PET data analysis, Quantitative Biology 2016, 4(3): 217–225

                2.魏磊,袁野,汪小我*,合成基因線路規模化設計面臨的挑戰,中國生物工程學報,2017,33(3):372-385

                3.Zhe Cao#, Chang Liu#, Jianwei Xu#, Lei You, Chunyou Wang, Wenhui Lou, Bei Sun, Yi Miao, Xubao Liu, Xiaowo Wang*, Taiping Zhang*, Yupei Zhao*, Plasma microRNA panels to diagnose pancreatic cancer: Results from a multicenter study, Oncotarget, 2016, 7(27):41575-41583

                4.Ye Yuan, Xinying Ren, Zhen Xie, Xiaowo Wang*, A quantitative understanding of microRNA-mediated competing endogenous RNA regulation, Quantitative Biology 4 (1), 47-57

                5.Chao He, Michael Q. Zhang*, Xiaowo Wang*, MICC: an R package for identifying chromatin interactions from ChIA-PET data, Bioinformatics, 2015, 31(23): 3832-4

                6.Honglei Liu, Zheng Wei, Antonia Dominguez, Yanda Li, Xiaowo Wang*, Lei S. Qi*, CRISPR-ERA: a comprehensive design tool for CRISPR-mediated gene editing, repression and activation, Bioinformatics, 2015, 31(22):3676-8

                7.梁亞茹#, 劉暢#, 王卓然, 董瓊葉, 汪小我*, 王釗*. 抗衰老藥物對線蟲生存曲線影響的薈萃分析. 中國科學 生命科學, 2015, 45(5): 479-487

                8.Ye Yuan, Bing Liu, Peng Xie, Michael Q. Zhang, Yanda Li, Zhen Xie*, Xiaowo Wang*, Model-guided quantitative analysis of microRNA-mediated regulation on competing endogenous RNAs using a synthetic gene circuit, Proc Natl Acad Sci U S A, 2015, 112(10):3158-63

                9.Honglei Liu, Yanda Li, Xiaowo Wang*, OP-Synthetic: identification of optimal genetic manipulations for the overproduction of native and non-native metabolites, Quantitative Biology 2014, 2(3): 100?109

                10.Chao He, Xiaowo Wang*, Michael Q. Zhang*, Nucleosome eviction and multiple co-factor binding predict estrogen-receptor-alphaassociated long-range interactions, Nucleic Acid Research, 2014, 42(11):6935-44

                11.Peng Xie, Yu Liu, Yan-da Li, Michael Zhang* and Xiaowo Wang*, MIROR: a method for cell-type specific microRNA occupancy rate prediction, Mol. BioSyst. 2014, 10 (6), 1377 - 1384

                12.YingXue Li, XueNing Liu, Xiaowo Wang, XueGong Zhang, Sequence signatures of genes with accompanying antisense transcripts in Saccharomyces cerevisiae, Science China Life Sciences, 2014 Jan;57(1):52-58

                13.Yong Chen, Yunfeng Ding, Yi Yang, Jinhai Yu, Guiing Liu, Xumin Wang, Shuyan Zhang, Dan Yu, Lai Song, Hangxiao Zhang, Congyan Zhang, Linhe Huo, Chaoxing Huo, Yang Wang, Yalan Du, Huina Zhang, PengZhang, Huimin Na, Shimeng Xu, Yaxin Zhu, Zhensheng Xie, Tong He, Yue Zhang, Guoliang Wang, Zhonghua Fan, Honglei Liu, Xiaowo Wang, Xuegong Zhang, Michael Q. Zhang, Yanda Li, Alexander Steinbuchel,Toyoshi Fujimoto, Simon Cichello, Jun Yu, Pingsheng Liu, Integrated omics study delineates the dynamics of lipid droplets in Rhodococcus opacus PD630, Nucleic Acids Research, 2014, 42(2):1052-64

                14.Matthew H Larson, Luke A Gilbert, Xiaowo Wang, Wendell A Lim, Jonathan S Weissman & Lei S Qi, CRISPR interference (CRISPRi) for sequence-specific control of gene expression, Nature Protocols, 2013; 8, 2180?2196

                15.Ruijuan Li, Weilong Guo, Jin Gu, Michael Q. Zhang, Xiaowo Wang*, Chromatin state and microRNA determine different gene expression dynamics responsive to TNF stimulation, Genomics, 2012 ;100(5):297-302

                16.Ozlem Aksoy, Agustin Chicas, Tianying Zeng, Zhen Zhao, Mila McCurach, Xiaowo Wang, Scott Lowe, The atypical E2F family member E2F7 couples the p53 and Rb pathways during cellular senescence, Genes Dev.2012; 26(14):1546-57

                17.Agustin Chicas#, Avnish Kapoor#, Xiaowo Wang#, Ozlem Aksoy, Adam G. Evertts, Michael Q. Zhang, Benjamin A. Garcia, Emily Bernstein*, Scott Lowe*, H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence, Proc Natl Acad Sci U S A. 2012 ;109(23):8971-6 (#equally contributed)

                18.Ratnakumar K, Duarte LF, Leroy G, Hasson D, Smeets D, Vardabasso C, Bonisch C, Zeng T, Xiang B, Zhang DY, Li H, Wang X, Hake SB, Schermelleh L, Garcia BA, Bernstein E., ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression, Genes Dev. 2012 Mar 1;26(5):433-8.

                19.Miao He, Yu Liu, Xiaowo Wang, Michael Q. Zhang, Gregory Hannon, Z. Josh Huang, Cell-type based analysis of microRNA profiles in the mouse brain, Neuron, 2012, 73(1):35-48

                20.Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE, Premsrirut P, Luo W, Chicas A, Lee CS, Kogan SC, Lowe SW, Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity, Genes Dev.;25(20):2125-36, 2011

                21.Wang LY, Wang P, Li MJ, Qin J, Wang X, Zhang MQ, Wang J. EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans. Epigenetics. 2011 Dec 1;6(12):1505-12.

                22.Likun Wang, Xiaowo Wang, Xi Wang, Xuegong Zhang, Yanchun Liang, Observations on novel splice junctions from RNA sequencing data, Biochemical and Biophysical Research Communications, 409(2):299-303, 2011

                23.王曦, 汪小我, 王立坤, 馮智星, 張學工, 新一代高通量RNA測序數據的墨麒麟平静處理與分析, 生物化學與生物物理進展, 37(8):834-846, 2010

                24.Agustin Chicas, Xiaowo Wang, Chaolin Zhang, Mila McCurrach, Zhen Zhao, Ozlem Mert, Ross A. Dickins, Masashi Narita, Michael Zhang and Scott W. Lowe, Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence, Cancer Cell, 17(4): 376-387, 2010

                25.Tingting Li, Xueya Zhou, Xiaowo Wang, Dahai Zhu, Yong Zhang, Identification and characterization of human snoRNA core promoters, Genomics, 96(1):50-6, 2010

                26.Likun Wang, Zhixing Feng, Xi Wang, Xiaowo Wang*, Xuegong Zhang*, DEGseq: an R package for identifying differentially expressed genes from RNA-seq data, Bioinformatics, 26(1):136-138 2010

                27.Xiaowo Wang, Zhenyu Xuan, Xiaoyue Zhao, Yanda Li, Michael Q. Zhang, High-resolution human core-promoter prediction with CoreBoost_HM, Genome Research, 19(2):266-75, 2009

                28.Xiaowo Wang , Jin Gu, Michael Q. Zhang and Yanda Li., Identification of phylogenetically conserved microRNA cis-regulatory elements across 12 Drosophila species, Bioinformatics, 15;24(2):165-71,2008

                29.Tao Peng, Chenghai Xue, Jianning Bi, Tingting Li, Xiaowo Wang, Xuegong Zhang and Yanda Li, Functional importance of different patterns of correlation between adjacent cassette exons in human and mouse, BMC Genomics, 26;9:191, 2008

                30.Xiaowo Wang , Xuegong Zhang, Yanda Li, Complicated evolutionary patterns of miRNAs in vertebrates, Sci China Ser C-Life Sci, 51(6):552-9 2008

                31.汪小我,張學工,李衍達,脊椎動物中微小RNA進◣化模式研究, 中國科學C輯:生命科學,2008, 38(4):348-355

                32.Jian Huang, Pei Hao, Yun-Li Zhang, Fu-Xing Deng, Qing Deng, Yi Hong, Xiaowo Wang, Yun Wang, Ting-Ting Li, Xue-Gong Zhang, Yi-Xue Li, Peng-Yuan Yang, Hong-Yang Wang and Ze-Guang Han. Discovering multiple transcripts of human hepatocytes using massively parallel signature sequencing (MPSS), BMC Genomics, 8:207,2007

                33.Jin Gu, Tao He, Yunfei Pei, Fei Li, Xiaowo Wang, Jing Zhang, Xuegong Zhang and Yanda Li, Primary Transcripts and Expressions of Mammal Intergenic MicroRNAs Detected by Mapping ESTs to Their Flanking Sequences. Mamm Genome, 17(10):1033-1041, 2007

                34.Xiaowo Wang, Jing Zhang, Fei Li , Jin Gu , Tao He , Xuegong Zhang and Yanda Li, MicroRNA identification based on sequence and structure alignment. Bioinformatics, 21 (18): 3610-4, 2005


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