• <tr id='HhAHJF'><strong id='HhAHJF'></strong><small id='HhAHJF'></small><button id='HhAHJF'></button><li id='HhAHJF'><noscript id='HhAHJF'><big id='HhAHJF'></big><dt id='HhAHJF'></dt></noscript></li></tr><ol id='HhAHJF'><option id='HhAHJF'><table id='HhAHJF'><blockquote id='HhAHJF'><tbody id='HhAHJF'></tbody></blockquote></table></option></ol><u id='HhAHJF'></u><kbd id='HhAHJF'><kbd id='HhAHJF'></kbd></kbd>

    <code id='HhAHJF'><strong id='HhAHJF'></strong></code>

    <fieldset id='HhAHJF'></fieldset>
          <span id='HhAHJF'></span>

              <ins id='HhAHJF'></ins>
              <acronym id='HhAHJF'><em id='HhAHJF'></em><td id='HhAHJF'><div id='HhAHJF'></div></td></acronym><address id='HhAHJF'><big id='HhAHJF'><big id='HhAHJF'></big><legend id='HhAHJF'></legend></big></address>

              <i id='HhAHJF'><div id='HhAHJF'><ins id='HhAHJF'></ins></div></i>
              <i id='HhAHJF'></i>
            1. <dl id='HhAHJF'></dl>
              1. <blockquote id='HhAHJF'><q id='HhAHJF'><noscript id='HhAHJF'></noscript><dt id='HhAHJF'></dt></q></blockquote><noframes id='HhAHJF'><i id='HhAHJF'></i>
                師資隊伍
                汪小我

                信息處理研究所 副所長

                北京信息为了那科學與技術國家研究中心生物信息學部

                生物信息學教育部重點實驗室

                清華大學合成與系統生物向夜来香酒吧赶去學中心

                個人主頁:http://bioinfo.au.tsinghua.edu.cn/member/xwwang/

                電話: 010-62794294 轉808
                地點:北京清華大从刚刚突破武士一级學FIT 1-112室


                教育背景


                1999年8月–2003年7月 清華大學,自動化系,自動化他们專業,學士

                2007年9月–2008年3月 美國冷泉港實驗室,訪問學生

                2003年9月–2008年7月 清華大學,自動化系,控制科學與工程,博士


                工作履歷


                2008年7月–2011年11月 清華大學,自動化系,講師

                2011年12月–2015年12月 清華大學,自動化系,副教授

                2012年3月–2013年3月 美國加州大學伯克利分校,唐氏傑出學者

                2016年1月–現在 清華大學,自動化系,長聘副教授(Tenure,PI,博天才士生導師)


                學術兼職


                中國人工智能學會生物信息學與人工生命專業委員會副主任

                中國生物工程學會青←年工作委員會主任

                中國生物工程學一条虚无會理事

                中國計算機學會生物→信息學專委會常務委員

                中國自動化學會青年工作委員會委員

                Quantitative Biology 編委

                系統科學與數學身上就这点钱 編委

                合成但这一世生物學 編委

                擔任國家自然科學基金項目函評人,以及Nature Biotechnology, PNAS, Genome Biolgy, Bioinformatics、PLoS Computational Biology,《科學通報》、《中國科學》等國內外期刊和會議的審稿人


                研究領域


                1.生物信息學研究

                2.生物組學大數據的信息挖掘

                3.模式識別與機器學習方法及應用

                4.合成生物系統的設計與控制


                獎勵湖水轻轻动荡與榮譽


                中國】自動化學會青年科學家獎,2019

                國家自然科學基金優秀青年基金,2013

                教育部新世紀優秀⊙人才,2013

                全國優秀博士學位論任何拥有它文,2010

                中國自動化學會科學技術進步獎二等獎(排名第二),2013

                國家教學成果二等獎(排名第五),2009

                北京市教學而且成果一等獎(排名第五),2008


                學術成果


                1.Lei Wei#, Ye Yuan#, Tao Hu, Shuailin Li, Tianrun Cheng, Jinzhi Lei, Zhen Xie, Michael Q. Zhang, Xiaowo Wang*, Regulation by competition: a hidden layer of gene regulatory network, Quantitative Biology, 2019; 7(2): 110–121

                2. Zhao Z, Dong QY, Liu XH, Wei L, Liu LY, Li YD, Wang XW*, Dynamic transcriptome profiling in DNA damage-induced cellular senescence and transient cell-cycle arrest. Genomics. 2019, doi: 10.1016/j.ygeno.2019.07.020

                3. Xiong, Guangbing#; Liu, Chang#; Yang, Gang; Feng, Mengyu; Xu, Jianwei; Zhao, Fangyu; You, Lei; Zhou, Li; Zheng, Lianfang; Hu, Ya; Wang, Xiaowo; Zhang, Taiping*; Zhao, Yupei*; Long noncoding RNA GSTM3TV2 upregulates LAT2 and OLR1 by competitively sponging let-7 to promote gemcitabine resistance in pancreatic cancer, Journal of Hematology & Oncology, 2019, 12(1):97

                4. Liu XH#, Wei L#, Dong QY, Liu LY, Zhang MQ, Xie Z, Wang XW*, A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. Aging (Albany NY). 2019 ;11(12):4011-4031

                5. 方歡,鐘碧溪,魏磊,張祥林,張威,汪小我*;血漿遊離DNA全基因組甲基化測序的實用穩定性評估 , 生物工程▂學報, 2019, 35(12): 2284-2294

                6. 張祥林, 方歡, 汪小我*, 三維基因組數據分析方法進展,《生物化學與生物物理進展》 2018, 45(11): 1093-1105

                7. 胡冠華,王也,魏磊,汪小我*, 通過合成基因線路實現細胞分類,《生命科學》 2018, 30(8): 799-809

                8. Dong Q, Wei L, Zhang MQ*, Wang XW*, Regulatory RNA binding proteins contribute to the transcriptome-wide splicing alterations in human cellular senescence, Aging (Albany NY). 2018, 10(6):1489-1505.

                9. Miao Z, Deng K, Wang X, Zhang X*, DEsingle for detecting three types of differential expression in single-cell RNA-seq data, Bioinformatics, 2018, 34(18):3223-3224

                10. Yaru Liang#, Chang Liu#, Maoyang Lu, Qiongye Dong, Zimu Wang, Zhuoran Wang,Wenxiang Xiong, Nannan Zhang, Jiawei Zhou, Qingfei Liu, Xiaowo Wang*, Zhao Wang*,Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves, Scientific Reports, 2018, 8:5779, DOI:10.1038/s41598-018-24146-z

                11. Wei Z#, Zhang W#, Fang H, Li Y, Wang X* esATAC: An Easy-to-use Systematic pipeline for ATAC-seq data analysis. Bioinformatics. 2018, 34(15):2664-2665

                12. Li Y#, Zheng H#, Wang Q, Zhou C, Wei L, Liu X, Zhang W, Zhang Y, Du Z, Wang X, Xie W*. Genome-wide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valleys. Genome Biol. 2018 Feb 8;19(1):18

                13. Du Z, Zheng H, Huang B, Ma R, Wu J, Zhang X, He J, Xiang Y, Wang Q, Li Y, Ma J, Zhang X, Zhang K, Wang Y, Zhang MQ, Gao J, Dixon JR, Wang X, Zeng J, Xie W*. Allelic reprogramming of 3D chromatin architecture during early mammalian development. Nature. 2017;547(7662):232-235.

                14. Dong Q#, Han H#, Liu X#, Wei L, Zhang W, Zhao Z, Zhang MQ, Wang X*, HCSGD: An integrated database of human cellular senescence genes., J Genet Genomics. 2017; 44(5): 227-234

                15. Honglei Liu, Xiaowo Wang*, Lei S. Qi*, Using CRISPR-ERA Webserver for sgRNA Design, Bio-protocals, 2017, DOI:10.21769/BioProtoc.2522

                16. 魏磊, 袁野, 汪小我*, 合成基因線路規模化設計面臨的挑戰. 生物工程學報. 2017;33(3):372-385.

                17. 張學工*, 江瑞, 汪小我, 古槿, 陳挺,從生物大數據到知識大發現: 十年進展與未來展望,科學通報,2016, 61(36), 3869-3877

                18. Cao Z#, Liu C#, Xu J, You L, Wang C, Lou W, Sun B, Miao Y, Liu X, Wang X*, Zhang T*, Zhao Y*, Plasma microRNA panels to diagnose pancreatic cancer: Results from a multicenter study. Oncotarget. 2016;7(27):41575-41583

                19. Chao He#, Guipeng Li#, Diekidel M. Nadhir, Yang Chen*, Xiaowo Wang*, Michael Q. Zhang*, Advances in computational ChIA-PET data analysis, Quantitative Biology, 2016, 4(3): 217-225

                20. Ye Yuan#, Xinying Ren#, Zhen Xie, Xiaowo Wang*, A quantitative understanding of microRNA-mediated competing endogenous RNA regulation, Quantitative Biology 4 (1), 47-57

                21. Chao He, Michael Q. Zhang*, Xiaowo Wang*, MICC: an R package for identifying chromatin interactions from ChIA-PET data, Bioinformatics, 2015, 31(23): 3832-4

                22. Honglei Liu, Zheng Wei, Antonia Dominguez, Yanda Li, Xiaowo Wang*, Lei S. Qi*, CRISPR-ERA: a comprehensive design tool for CRISPR-mediated gene editing, repression and activation, Bioinformatics, 2015, 31(22):3676-8

                23. 梁亞茹#, 劉暢#, 王卓然, 董瓊葉, 汪小我*, 王釗*. 抗衰老藥物對喝道線蟲生存曲線影響的薈萃分析. 中國科學 生命科學, 2015, 45(5): 479-487

                24. Ye Yuan#, Bing Liu#, Peng Xie, Michael Q. Zhang, Yanda Li, Zhen Xie*, Xiaowo Wang*, Model-guided quantitative analysis of microRNA-mediated regulation on competing endogenous RNAs using a synthetic gene circuit, PNAS. 2015, 112(10):3158-63

                25. Honglei Liu, Yanda Li, Xiaowo Wang*, OP-Synthetic: identification of optimal genetic manipulations for the overproduction of native and non-native metabolites, Quantitative Biology. 2014, 2(3): 100–109

                26. Chao He, Xiaowo Wang*, Michael Q. Zhang*, Nucleosome eviction and multiple co-factor binding predict estrogen-receptor-alpha associated long-range interactions, Nucleic Acid Research, 2014, 42(11):6935-44

                27. Peng Xie#, Yu Liu#, Yan-da Li, Michael Zhang* and Xiaowo Wang*, MIROR: a method for cell-type specific microRNA occupancy rate prediction, Mol. BioSyst. 2014, 10(6):1377-84

                28. YingXue Li, XueNing Liu, Xiaowo Wang, XueGong Zhang*, Sequence signatures of genes with accompanying antisense transcripts in Saccharomyces cerevisiae, Science China Life Sciences, 2014 Jan;57(1):52-58

                29. Yong Chen, Yunfeng Ding, Yi Yang, Jinhai Yu, Guiing Liu, Xumin Wang, Shuyan Zhang, Dan Yu, Lai Song, Hangxiao Zhang, Congyan Zhang, Linhe Huo, Chaoxing Huo, Yang Wang, Yalan Du, Huina Zhang, Peng Zhang, Huimin Na, Shimeng Xu, Yaxin Zhu, Zhensheng Xie, Tong He, Yue Zhang, Guoliang Wang, Zhonghua Fan, Honglei Liu, Xiaowo Wang, Xuegong Zhang, Michael Q. Zhang, Yanda Li, Alexander Steinbuchel, Toyoshi Fujimoto, Simon Cichello, Jun Yu, Pingsheng Liu*, Integrated omics study delineates the dynamics of lipid droplets in Rhodococcus opacus PD630, Nucleic Acids Research, 2014, 42(2):1052-64

                30. Matthew H Larson, Luke A Gilbert, Xiaowo Wang, Wendell A Lim, Jonathan S Weissman, Lei S Qi*, CRISPR interference (CRISPRi) for sequence-specific control of gene expression, Nature Protocols, 2013; 8, 2180–2196

                31. Ruijuan Li, Weilong Guo, Jin Gu, Michael Q. Zhang, Xiaowo Wang*, Chromatin state and microRNA determine different gene expression dynamics responsive to TNF stimulation, Genomics, 2012 ;100(5):297-302

                32. Ozlem Aksoy#, Agustin Chicas#, Tianying Zeng, Zhen Zhao, Mila McCurach, Xiaowo Wang, Scott Lowe*, The atypical E2F family member E2F7 couples the p53 and Rb pathways during cellular senescence, Genes Dev. 2012; 26(14):1546-57

                33. Agustin Chicas#, Avnish Kapoor#, Xiaowo Wang#, Ozlem Aksoy, Adam G. Evertts, Michael Q. Zhang, Benjamin A. Garcia, Emily Bernstein*, Scott Lowe*, H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence, PNAS. 2012 ;109(23):8971-6 (?equally contributed)

                34. Ratnakumar K, Duarte LF, Leroy G, Hasson D, Smeets D, Vardabasso C, Bonisch C, Zeng T, Xiang B, Zhang DY, Li H, Wang X, Hake SB, Schermelleh L, Garcia BA, Bernstein E*, ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression, Genes Dev. 2012 Mar 1;26(5):433-8.

                35. Miao He, Yu Liu, Xiaowo Wang, Michael Q. Zhang, Gregory Hannon, Z. Josh Huang*, Cell-type based analysis of microRNA profiles in the mouse brain, Neuron, 2012, 73(1):35-48

                36. 董瓊葉,汪小我*,劉平生,張奇偉,脂滴表面蛋白質的預測和分類 中國科技

                37. 論文在線精品論文, 2012, 5(17): 1667-1673

                38. Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE, Premsrirut P, Luo W, Chicas A, Lee CS, Kogan SC, Lowe SW, Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity, Genes Dev.;25(20):2125-36, 2011

                39. Wang LY, Wang P, Li MJ, Qin J, Wang X, Zhang MQ, Wang J. EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans. Epigenetics. 2011 Dec 1;6(12):1505-12.

                40. Likun Wang, Xiaowo Wang, Xi Wang, Yanchun Liang, Xuegong Zhang*, Observations on novel splice junctions from RNA sequencing data, Biochemical and Biophysical Research Communications, 409(2):299-303, 2011

                41. Agustin Chicas, Xiaowo Wang, Chaolin Zhang, Mila McCurrach, Zhen Zhao, Ozlem Mert, Ross A. Dickins, Masashi Narita, Michael Zhang and Scott W. Lowe*, Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence, Cancer Cell, 17(4): 376-387, 2010

                42. Xi Wang, Xiaowo Wang, Likun Wang, Zhixing Feng, Xuegong Zhang*, A review on the processing and analysis of next-generation RNA-seq data,Prog. Biochem. Biophys., 37(8):834-846, 2010 (In Chinese)

                43. Tingting Li, Xueya Zhou, Xiaowo Wang, Dahai Zhu*, Yong Zhang*, Identification and characterization of human snoRNA core promoters, Genomics, 96(1):50-6, 2010

                44. Likun Wang, Zhixing Feng, Xi Wang, Xiaowo Wang*, Xuegong Zhang*, DEGseq: an R package for identifying differentially expressed genes from RNA-seq data, Bioinformatics, 26(1):136-138 2010 (*co-corresponding Author)

                45. Xiaowo Wang#, Zhenyu Xuan#, Xiaoyue Zhao, Yanda Li, Michael Q. Zhang*, High-resolution Human Core-promoter prediction with CoreBoost_HM, Genome Research, 19: 266-275 2009

                46. Tao Peng, Chenghai Xue, Jianning Bi, Tingting Li, Xiaowo Wang, Xuegong Zhang, Yanda Li*, Functional importance of different patterns of correlation between adjacent cassette exons in human and mouse, BMC Genomics, 26;9:191, 2008

                47. 李婷婷,蔣博,汪小我,張學工* 轉錄因子結合位點的計算分析方法 生物物理學報, 2008, 24(05): 334-347

                48. Xiaowo Wang, Jin Gu, Michael Q. Zhang and Yanda Li*, Identification of phylogenetically conserved microRNA cis-regulatory elements across 12 Drosophila species, Bioinformatics, 2008, 15;24(2):165-71

                49. Xiaowo Wang, Xuegong Zhang, Yanda Li*, Complicated evolutionary patterns of miRNAs in vertebrates, Sci China Ser C-Life Sci, 51(6):552-9 2008

                50. Jian Huang, Pei Hao, Yun-Li Zhang, Fu-Xing Deng, Qing Deng, Yi Hong, Xiaowo Wang, Yun Wang, Ting-Ting Li, Xue-Gong Zhang, Yi-Xue Li, Peng-Yuan Yang, Hong-Yang Wang and Ze-Guang Han*. Discovering multiple transcripts of human hepatocytes using massively parallel signature sequencing (MPSS), BMC Genomics, 8:207,2007

                51. Jin Gu#, Tao He#, Yunfei Pei, Fei Li, Xiaowo Wang, Jing Zhang, Xuegong Zhang, Yanda Li*, Primary Transcripts and Expressions of Mammal Intergenic MicroRNAs Detected by Mapping ESTs to Their Flanking Sequences. Mamm Genome, 17(10):1033-1041, 2006

                52. Xiaowo Wang#, Jing Zhang#, Fei Li, Jin Gu , Tao He , Xuegong Zhang and Yanda Li*, MicroRNA identification based on sequence and structure alignment. Bioinformatics, 2005, 21 (18): 3610-4